Download First Principles of Gastroenterology : The Basis of Disease and an Approach to Management 5th ed PDF

First Principles of Gastroenterology : The Basis of Disease and an Approach to Management 5th ed
Name: First Principles of Gastroenterology : The Basis of Disease and an Approach to Management 5th ed
Author: staff
Pages: 890
Year: 2005
Language: English
File Size: 12.91 MB
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List of Contributors ADAMS, P.C., London Health Sciences Centre University Campus, 339 Windermere Rd., London, ON N6A 5A5. Tel: (519) 858 5125 Fax: (519) 858 5114 E mail: [email protected] ALLARD, J.P., University Health Network Toronto General Hospital, EW 217A 200 Elizabeth St., Toronto, ON M5G 2C4. Tel: (416) 340 5159 Fax: (416) 348 0065 E mail: [email protected] ARCHAMBAULT, A.P., H pital Maisonneuve Rosemont, 5415 boulevard de l'Assomption, Montr al, QC H1T 2M4. Tel: (514) 252 3822 Fax: (514) 252 3486 ARMSTRONG, D., Associate Professor, Division of Gastroenterology, Chief of Clinical Service, Division of Gastroenterology, Hamilton Health Sciences, McMaster University Medical Centre, HSC 4W8 1200 Main St. W, Hamilton, ON L8N 3Z5. Tel: (905) 521 2100 ext. 76404 Fax: (905) 521 4958 E mail: [email protected] BAIK, S.K., Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, 162 Ilsan dong, Wonju, South Korea 220 701. Tel: (82) 33 741 1223 Fax: (82) 33 745 6782 E mail: [email protected] BAIN, V.G., Director, Liver Unit, University of Alberta, 205 College Plaza, 8215 112th St., Calgary, AB T6G 2C8. Tel: (780) 492 8128 Fax: (780) 492 8130 E mail: [email protected] BECK, I.T., Gastroenterology/Internal Medicine, Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 0225 Fax: (613) 544 3114 E mail: [email protected]


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2list of contributors BURKE, J., Queen Elizabeth II Health Sciences Centre, 1278 Tower Rd., Halifax, NS B3H 2Y9. Tel: (902) 473 7770 Fax: (902) 473 5323 BURNSTEIN, M., Program Director, Colon and Rectal Surgery, University of Toronto, Interim Division Head, General Surgery, St. Michael's Hospital, 38 Shuter St., Suite 504, Toronto, ON M5B 1A6. Tel: (416) 864 6050 Fax: (416) 864 5668 E mail: [email protected] BURSEY, R.F., Associate Professor of Medicine, Memorial University, Health Sciences Centre, 300 Prince Philip Dr., St. John's, NL A1B 3V6. Tel: (709) 777 6960 Fax: (709) 777 8044 E mail: [email protected] BUTZNER, J.D., Head, Division of Gastroenterology and Nutrition, Alberta Children's Hospital, 1820 Richmond Rd. SW, Calgary, AB T2T 5C7. Tel: (403) 943 7721 Fax: (403) 943 2203 E mail: [email protected] CHAMPION, M.C., Internal Medicine/Gastroenterology, The Ottawa Hospital Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4674 Fax: (613) 761 5269 E mail: [email protected] DUB , C., Division of Gastroenterology, The Ottawa Hospital, 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4603 Fax: (613) 761 5068 E mail: [email protected] FARDY, J.M., Gastroenterology/Internal Medicine, Memorial University, Faculty of Medicine, Health Sciences Centre, 300 Prince Philip Dr., St John's, NF A1B 3V6. Tel: (709) 777 7064 Fax: (709) 777 8044 E mail: [email protected] FARIA, J., Division of Colon and Rectal Surgery, G308 Sir Mortimer B. Davis Jewish General Hospital, 3755 ch Cote Sainte Catherine, Montreal, QC H3T 1E2. Tel: (514) 340 8222 Fax: (514) 340 7560 E mail: [email protected] FEAGAN, B.G., Professor of Medicine, Epidemiology and Biostatistics, University of Western Ontario, Director, Robarts Clinical Trials, Robarts Research Institute, 100 Perth Dr., London, ON N6A 5K8. Tel: (519) 663 3589 Fax: (519) 663 3807 E mail: [email protected] FEDORAK, R.N., Professor of Medicine, Director, Department of Gastroenterology, University of Alberta, Zeidler Ledcor Center, 130 University Campus, Edmonton, AB T6G 2H8. Tel: (780) 492 6941 Fax: (780) 492 8121 E mail: [email protected] FREEMAN, H.J., Gastroenterology, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5. E mail: [email protected] GAISANO, H., University Health Network, Toronto Western Hospital, 6B Fell 6 176, 399 Bathurst St., Toronto, ON M5T 2S8. Tel: (416) 603 5949 E mail: [email protected]


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list of contributors3 GIRGRAH, N., The Toronto Hospital, General Division, 11 NCSB 1238, 200 Elizabeth St., Toronto, ON M5G 2C4. Tel: (416) 340 5221 Fax: (416) 340 3492 E mail: [email protected] GREENBERG, G.R., Professor of Medicine, University of Toronto, Division of Gastroenterology, Mt. Sinai Hospital, 600 University Ave., Suite 445, Toronto, ON M5C 1X5. E mail: [email protected] GR GOIRE, S., Gastroenterology, The Ottawa Hospital General Campus, 203 311 McArthur Ave., Vanier, ON K1L 8M3. Tel: (613) 744 8180 Fax: (613) 744 7982 E mail: [email protected] GROVER, P.T., Senior GI Fellow, Division of Gastroenterology, University of Alberta, 8440 112th St., Edmonton, AB T6G 2R7. Tel: (780) 492 8146 Fax: (780) 492 8148 HABAL, F., Gastroenterology, Toronto General Hospital, 200 Elizabeth St., Office 9N977, Toronto, ON M5G 2C4. E mail: [email protected] HEATHCOTE, J., The Toronto Western Hospital, University Health Network, University of Toronto, 6B Fell Wing 172, 399 Bathurst St., Toronto, ON M5T 2S8. Tel: (416) 603 5914 Fax: (416) 603 5914 E mail: [email protected] HUNT, R.H., Professor of Medicine and Gastroenterology, Division of Gastroenterology, McMaster University Medical Centre, McMaster University, Room 4W8, 1200 Main St. W, Hamilton, ON L8N 3Z5. Tel: (905) 521 2100 ext. 73219 Fax: (905) 521 5072 Cell: (905) 541 8777 GSM: 44 7785 260 430 E mail: [email protected] HURLBUT, D.J., Department of Pathology and Molecular Medicine, Kingston General Hospital, 76 Stuart St., Kingston, ON K7L 2V7. Tel: (613) 549 6666 ext. 6035 Fax: (613) 548 6076 E mail: [email protected] KICHIAN, G., Staff Gastroenterologist, Queensway Carleton Hospital, Suite 302 3029 Carling Ave., Ottawa, ON K2B 8E8. Tel: (613) 728 1795 Fax: (613) 728 0091 E mail: [email protected] LEE, S.S., Department of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1. Tel: (403) 220 3245 Fax: (403) 270 0995 E mail: [email protected] LEVY, G., Director, Multi Organ Transplant Program, University Health Network, University of Toronto, 585 University Ave., 11 NCSB 1236, Toronto, ON M5G 2N2. Tel: (416) 340 5166 Fax: (416) 340 3378 E mail: [email protected] LILLY, L.B., University Health Network, 11 NCSB 1241, 585 University Ave., Toronto, ON M5G 2N2. Tel: (416) 340 4629 Fax: (416) 340 3492 E mail: [email protected]


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4list of contributors MA, M., Hepatology and Gastroenterology, University of Alberta, 8440 112th St., Edmonton, AB T6G 2R7. Tel: (780) 492 8146 Fax: (780) 492 8148 E mail: [email protected] MACDONALD, P.H., Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3400 Fax: (613) 546 4854 E mail: [email protected] MACHIDA, H., Clinical Associate Professor, University of Calgary, Pediatric Gastroenterologist, Alberta Children's Hospital, 1820 Richmond Rd. SW, Calgary, AB T2T 5C7. Tel: (403) 943 7285 Fax: (403) 943 7321 E mail: [email protected] MACINTOSH, D.G., Associate Professor of Medicine (Gastroenterology), Dalhousie University, Queen Elizabeth II Health Sciences Centre Victoria General Site, Centennial Wing, 1278 Tower Rd., Room 927, Halifax, NS B3H 2Y9. Tel: (902) 473 3721 Fax: (902) 473 4406 E mail: [email protected] MARSHALL, J.K., Gastroenterology/Internal Medicine, McMaster University Medical Centre, 1200 Main St. W, Room 4W8, Hamilton, ON L8S 4J9. Tel: (905) 521 2100 ext. 76782 Fax: (905) 521 4958 E mail: [email protected] MARTIN, S.R., Service de gastro ent rologie h patologie et nutrition, H pital Sainte Justine, Universit de Montr al, 3175 C te Sainte Catherine, Montr al, QC H3T 1C5. Tel: (514) 345 4626 Fax: (514) 345 4999 E mail: [email protected] MAY, G.R., Associate Professor of Medicine, Head of Therapeutic Endoscopy, Division of Gastroenterology, University of Toronto, 16 058 CC, St Michael's Hospital, 30 Bond St., Toronto, ON M5B 1W8. Tel: (416) 864 5345 Fax: (416) 864 5749 E mail: [email protected] MAYRAND, S., Gastroenterology/Internal Medicine, MUHC Montreal General Hospital, D7 120 1650 av Cedar, Montreal, QC H3G 1A4. Tel: (514) 934 8308 Fax: (514) 934 8375 E mail: [email protected] MERCER, C.D., General Surgery, Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3400 Fax: (613) 546 4854 E mail: [email protected] MOAYYEDI, P., Professor of Gastroenterology, Department of Medicine, Division of Gastroenterology, McMaster University Medical Centre, 1200 Main St. W, HSC 3N51D, Hamilton, ON L8N 3Z5. Tel: (905) 525 9140 ext. 26688 Fax: (905) 522 3454 E mail: [email protected]


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list of contributors5 MYERS, R.P., Consulting Staff, Liver Unit, Department of Medicine, Division of Gastroenterology and Hepatology, University of Calgary, G126 3330 Hospital Dr. NW, Calgary, AB T2N 4N1. Tel: (403) 210 9363 Fax: (403) 210 9368 E mail: [email protected] PADOL, I.T., Research Associate, Department of Medicine, McMaster University Health Sciences Centre, 3N5 1200 Main St. W, Hamilton, ON L8N 3Z5. Tel: (905) 521 2100 ext. 22330 Fax: (905) 522 3454 E mail: [email protected] PAPALIA, P., Division of Gastroenterology, McGill University Health Centre, 1650 Cedar Ave., Montreal, QC H3G 1A4. Tel: (514) 934 8308 Fax: (514) 934 8411 PAR , P., Professeur agr g de clinique, M decine, Universit Laval, CHAUQ H pital du St Sacrement, 1050 Chemin Ste Foy, Quebec, PQ G1S 4L8. Tel: (418) 682 7511 ext. 4603 Fax: (418) 682 7855 E mail: [email protected] PARSONS, H.G., Pediatric Gastroenterology and Nutrition, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1. Tel: (403) 220 7496 Fax: (403) 283 3028 E mail: [email protected] PATEL, D.G., Professor of Medicine, Gastroenterology, The Ottawa Hospital Civic Campus, A1 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4501 Fax: (613) 761 5269 E mail: [email protected] PATERSON, W.G., Gastroenterology/Internal Medicine, Professor of Medicine, Biology and Physiology, Hotel Dieu Hospital, Queen's University, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3400 Fax: (613) 544 3114 E mail: [email protected] PELTEKIAN, K.M., Associate Professor of Medicine, Dalhousie University, Specialist in Hepatology and Liver Transplantation, Capital District Health Authority, 1278 Tower Rd., VG Site Room 6 302, Halifax, NS B3H 2Y9. Tel: (902) 473 2898 Fax: (902) 473 2783 E mail: [email protected], Web site: www.NSHepLink.dal.ca ROBERTS, E.A., Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Ave., Toronto, ON M5G 1X8. Tel: (416) 813 7733 Fax: (416) 813 4972 E mail: [email protected] ROBERTSON, M., Pediatric Gastroenterology and Nutrition, Alberta Children's Hospital, 1820 Richmond Rd. SW, Calgary, AB T2T 5C7. E mail: [email protected]


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6list of contributors ROMAGNUOLO, J., Associate Professor of Medicine, Director of Clinical Research, Division of Gastroenterology, Medical University of South Carolina (MUSC), 96 Jonathon Lucas St., CSB #210, P.O. Box 250 327, Charleston, SC 29425. Tel: (843) 792 9902 Fax: (843) 792 8395 E mail: [email protected] ROPELESKI, M.J., Gastroenterology/Internal Medicine, Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3400 ext. 2288 Fax: (613) 544 3114 E mail: [email protected] ROSSOS, P.G., Associate Professor of Medicine, University of Toronto, Program Director, University of Toronto Division of Gastroenterology, Director of Medical Informatics, University Health Network, Toronto General Hospital, 9N 975, 200 Elizabeth St., Toronto, ON M5G 2C4. Tel: (416) 340 5333 Fax: (416) 340 5335 ROSTOM, A., Division of Gastroenterology, University of Ottawa, Ottawa Hospital Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4603 Fax: (613) 761 5068 E mail: [email protected] SAGAR, M., Research Associate, General Surgeon, McMaster University, Division of Gastroenterology, AstraZeneca, M lndal, Sweden. E mail: [email protected] SALENA, B.J., Associate Professor of Medicine, McMaster University, Room 4W8, 1200 Main St. W, Hamilton, ON L8N 3Z5. SALOOJEE, N., Gastroenterology/Internal Medicine, The Ottawa Hospital General Campus, 501 Smyth Rd., Ottawa, ON K1H 8L6. Tel: (613) 737 7777 ext. 76420 Fax: (613) 739 6151 E mail: [email protected] SCULLY, L.J., Internal Medicine/Gastroenterology, The Ottawa Hospital Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4830 Fax: (613) 761 5269 E mail: [email protected] SEKAR, A.S.C., Gastroenterology, Parkdale Medical Tower, 504 1081 Carling Ave., Ottawa, ON K1Y 4G2. Tel: (613) 729 3179 Fax: (613) 729 1026 E mail: [email protected] SHAFFER, E.A., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB T2N 4N1. E mail: [email protected] SIMON, J.B., Division of Gastroenterology, Queen's University, Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3310 ext. 3482 Fax: (613) 544 3114 E mail: [email protected]


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THOMPSON, W.G., Emeritus Professor of Medicine, University of Ottawa, Chief of Gastroenterology, Ottawa Civic Hospital, 7 Nesbitt St., Ottawa, ON K2H 8C4. Tel: (613) 761 4147 Fax: (613) 828 7300 E mail: [email protected] THOMSON, A.B.R., Division of Gastroenterology, Department of Medicine, Zeidler Ledcor Centre, University of Alberta, 130 University Campus, Edmonton, AB T6G 2X8. Tel: (780) 492 6490 Fax: (780) 492 7964 E mail: [email protected] TURNBULL, G.K., Professor of Medicine, Dalhousie University, 1278 Tower Rd., Halifax, NS B3H 2Y9. Tel: (902) 473 4140 Fax: (902) 473 4406 E mail: [email protected] VANNER, S.J., Gastroenterology/Internal Medicine, Hotel Dieu Hospital, 166 Brock St., Kingston, ON K7L 5G2. Tel: (613) 544 3400 Fax: (613) 544 3114 E mail: [email protected] VILLENEUVE, J.P., CHUM H pital St Luc, 1058 rue Saint Denis, Montreal, QC H2X 3J4. Tel: (514) 890 8000 Fax: (514) 412 7314 E mail: [email protected] WATTERS, J.M., General Surgery, The Ottawa Hospital Civic Campus, 1053 Carling Ave., Ottawa, ON K1Y 4E9. Tel: (613) 761 4780 E mail: jw[email protected] WHITTAKER, J.S., Gastroenterology, 550 1144 Burrard St., Vancouver, BC V6Z 2A5. Tel: (604) 683 6393 Fax: (604) 681 2421 Hospital: (604) 682 2344 E mail: [email protected] WILD, G.E., Gastroenterology/Internal Medicine, MUHC Montreal General Hospital, D7 120 1650 av Cedar, Montreal, PQ H3G 1A4. Tel: (514) 937 6011 Fax: (514) 934 8411 E mail: [email protected] WONG, F., The Toronto Hospital, General Division, 200 Elizabeth St., Toronto, ON M5G 2C4. Tel: (416) 340 3834 Fax: (416) 340 5019 E mail: [email protected] WONG, W., 205 8215 112th St. NW, Edmonton, AB T6G 2C8. Tel: (780) 492 8134 Fax: (780) 492 8143 E mail: [email protected] WOROBETZ, L.J., Department of Gastroenterology, Royal University Hospital, University of Saskatchewan, 103 Hospital Dr., Saskatoon, SK S7N 0W8. Tel: (306) 966 7964 Fax: (306) 966 1254 E mail: [email protected] YUAN, C., Clinical Research Associate, Department of Medicine, McMaster University, E mail: [email protected] ZAMORA, S.A., H pital des Enfants, 6 rue Willy Donze, Geneva, Switzerland. Tel: (41) 22 382 45 16 Fax: (41) 22 382 45 04 E mail: [email protected]E.CH list of contributors7


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18 Proctalgia Fugax / W.G. Thompson40 19 Examination of the Abdomen / R.F. Bursey, J.M. Fardy, D.G. MacIntosh and N. Saloojee 41 Suggested Reading List 48 Practice Points 48 Nutrition in Gastrointestinal Disease. J.S. Whittaker,49 J.P. Allard and H.J. Freeman 1 Introduction 49 2 Essential Physiologic Concepts in Nutrition 49 3 Clinical and Laboratory Features of Protein Energy Malnutrition 55 4 Effects of Malnutrition on the Gastrointestinal Tract and Pancreas 56 5 Dietary Therapy in Gastrointestinal Disease 59 6 Dietary Therapy in Liver Disease 63 7 Nutrition Intervention 65 References 78 Suggested Reading List 78 Objectives 78 Pharmaceutical Research and Clinical Trials: The Basis79 for New Knowledge. B.G. Feagan and A. Archambault 1 Introduction 79 2 Clinical Research Regulations and Supervision 79 3 Clinical Drug Development 80 4 Methodology in Clinical Research 82 5 Planning a Clinical Trial 83 6 Informed Consent Form and Ethical Issues 85 7 Clinical Monitoring 85 8 Institutional Review Committee (IRC) 86 9 Reporting the Results of Clinical Research 86 10 Conclusion 86 Bibliography 87 The Esophagus.W.G. Paterson, S. Mayrand and C.D. Mercer88 1 Introduction 88 2 Anatomy 88 3 Physiology 90 4 Symptoms and Signs of Esophageal Diseases 94 5 Investigations Used in the Diagnosis of Esophageal Disease 97


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